Keywords : paper, soft lithography, bio-functionnalisation, paper-based lab on chip
Paper-based microfluidic devices have enjoyed rapid development since Georges Whiteside1 introduced the mPADs concept. A series of hydrophilic/hydrophobic microstructures on paper substrates were fabricated to construct mPADs using a variety of processing techniques. Compared to conventional microfluidic chips made of glass and polymer substrates, mPADs possess many unique advantages including, low-cost, ease of fabrication, strong capillary action and good biological compatibility for applications in clinical diagnosis and environmental monitoring.
We develop some easy to use techniques to pattern smart paper with biomolecules and produce paper-based lab on chip.
Fig: Soft lithogrphy of Streptavidin patterns Alexa 790nm (yellow) et Alexa 680 nm (magenta) on paper.
1: Andres W. Martinez, Scott T. Phillips, and George M. Whitesides, Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices, Anal. Chem. 2010, 82, 3–10